I-Guanidineacetic acid (GAA),ngeChemical Abstracts Service (CAS) inombolo 352-97-6, iyinhlanganisela eye yadonsa ukunaka emikhakheni ehlukahlukene, ikakhulukazi i-biochemistry kanye nokudla. Njengento ephuma ku-guanidine, i-GAA idlala indima ebalulekile ekuhlanganiseni i-creatine, isakhi esibalulekile sokugawulwa kwamandla kwezicubu zemisipha. Ukuqonda imisebenzi nokusetshenziswa kwe-guanidacetic acid kunganikeza ukuqonda ngokubaluleka kwayo empilweni nasekuthuthukiseni ukusebenza.
I-biochemistry
I-Guanidineacetic acidyaziwa ngokuyinhloko ngomsebenzi wayo njengesandulela se-creatine. I-Creatine iyi-molecule ebalulekile esiza ukukhiqiza i-adenosine triphosphate (ATP), umthwali wamandla oyinhloko emangqamuzaneni. Umzimba uhlanganisa i-creatine esuka ku-GAA ezinso bese uyihambisa emisipha nasebuchosheni. Le nqubo ibalulekile ekugcineni amazinga wamandla kanye nokusekela ukusebenza kwengqondo ngesikhathi sokuzivocavoca okukhulu.
Ukuguqulwa kwe-GAA ibe yi-creatine kubandakanya izinyathelo eziningi ze-enzymatic, lapho i-guanidinoacetate methyltransferase (GAMT) idlala indima ebalulekile. Le enzyme igqugquzela ukudluliswa kweqembu le-methyl lisuka ku-S-adenosylmethionine liye ku-guanidineacetic acid, lakha i-creatine. Ngakho-ke, i-GAA ingaphezu nje kwenhlanganisela elula; iyingxenye ebalulekile yezindlela ze-metabolic ezigcina ukukhiqizwa kwamandla emzimbeni.
Izinzuzo Zokunyakaza Nokuzivocavoca
Ngenxa yendima yayo ekuhlanganiseni i-creatine, i-guanidine acetic acid ithandwa ngabasubathi nabathandi bokuqina. Ukwengeza nge-GAA kungathuthukisa ukusebenza komzimba ngokwandisa ukutholakala kwe-creatine emisipha. Lokhu kuthuthukisa amandla, ukuphuma kwamandla, nokukhuthazela ngesikhathi sokusebenza okuphezulu. Ngaphezu kwalokho,I-GAAUkwengeza kungasiza ekunciphiseni ukukhathala kanye nokululama ngokushesha ngemva kokuzivocavoca, okwenza kube inketho ekhangayo kulabo abahlanganyela ezinhlotsheni zokuqeqesha ezinzima.
Ucwaningo lubonisa ukuthi i-GAA supplementation ingakhuphula imisipha futhi ithuthukise ukwakheka komzimba. Lokhu kunenzuzo ikakhulukazi kubasubathi abafuna ukuthuthukisa ukusebenza kwabo kuyilapho begcina imizimba ezondile. Ukwengeza, i-GAA isekela ukusebenza kwengqondo, okubalulekile kubasubathi okudingeka bahlale begxilile futhi bacabange ngokucacile ngesikhathi sokuncintisana.
Izicelo Zokwelapha Ezingenzeka
Ngaphezu kwezinzuzo zayo zokuzivivinya, ukusetshenziswa okungenzeka kokwelapha kwe-guanidine acetic acid nakho kuyahlolwa. Olunye ucwaningo luphakamisa ukuthi i-GAA ingaba nezakhiwo ze-neuroprotective, okuyenza ibe ikhandidethi lokucwaninga ngezifo ze-neurodeergenerative. Ikhono le-GAA lokukhulisa amazinga e-creatine ebuchosheni linganikeza ukuvikeleka ezifweni ezinjenge-Alzheimer's kanye nesifo sika-Parkinson, lapho umzimba we-energy uvame ukuba sengozini.
Ukwengeza, indima yeI-GAAekulawuleni ukuphazamiseka okuthile kwe-metabolic kuye kwacwaningwa. Ikhono layo lokuba nomthelela kumetabolism yamandla lingase libe nomthelela ezifweni ezifana nesifo sikashukela lapho ukusetshenziswa kwamandla kuphazamiseka khona. Ngokuthuthukisa ukusebenza kahle kokukhiqizwa kwamandla, i-GAA ingasiza ukuphatha kangcono amazinga kashukela egazini.
Ekuphetheni
Ngokufigqiwe,I-guanidine acetate (GAA) iyinhlanganisela enemisebenzi ebalulekile yamakhemikhali ezinto eziphilayo, ngokuyinhloko njengesandulela se-creatine. Indima yayo kumetabolism yamandla ibalulekile kubasubathi abafuna ukuthuthukisa ukusebenza nokululama. Ukwengeza, ucwaningo oluqhubekayo lwamandla ayo okwelapha lugqamisa ukusebenzisana kwe-GAA okungaphezu kokudla kwezemidlalo. Njengoba ukuqonda kwethu le nhlanganisela kuqhubeka nokuvela, i-guanidine acetic acid ingase idlale indima ebaluleke kakhulu ekusebenzeni kwezemidlalo nokuphathwa kwezempilo.
Isikhathi sokuthumela: Nov-04-2024