2- (4-Aminophyl) -1h-Benzimidazole-5-Amine, evame ukubizwa nge-APBIA, iyingxenye ye-CAS 7621-86-5. Ngenxa yezakhiwo zayo ezihlukile ezihlelekile nezinhlelo zokusebenza ezingaba khona, le ndawo idonsele ukunakwa emikhakheni ehlukahlukene, ikakhulukazi emikhakheni yamakhemikhali okwelapha amakhemikhali kanye nocwaningo lwezidakamizwa.
Ukwakheka kwamakhemikhali nezakhiwo
Ukwakheka kwamangqamuzana kwe-apbia kususelwa eBenziimidazole, okuyindlela eyenziwe ngamabhayisekili eyakhiwa indandatho ye-benzene esetshenzisiwe nendandatho ye-IMIDAZOLE. Ukuba khona kweqembu le-4-Aminophenyl kuthuthukisa ukusebenza kwalo kanye nokuxhumana ngezinjongo zebhayoloji. Lokhu kulungiswa kwesakhiwo kubalulekile ngoba kunomthelela kokusebenza kwendabuko kwe-compound, okwenza kube yisihloko sokuthuthuka kwezidakamizwa.
Isicelo kumakhemikhali wezokwelapha
Okunye kokusetshenziswa okuyisisekelo kwe-2- (4-aminophyl) -1h-Benzimidazole-5-Amine ukuthuthukiswa kwemithi. Abaphenyi bebelokhu behlola amandla bawo njengomuthi wokulwa nomdlavuza. I-Benzimidazole Moable yaziwa ngekhono layo lokuvimbela ama-enzyme ahlukahlukene kanye nama-receptors athinteka ekuqhubekeni komdlavuza. Ngokushintsha isakhiwo samakhemikhali sika-Apbia, ososayensi bahlose ukuthuthukisa ukusebenza kwayo nokukhetha okuphikisana nemigqa ethile yomdlavuza othile.
Ngaphezu kwalokho, i-APBIA iyafundwa ngendima yayo ekwelapheni ezinye izifo, kufaka phakathi izifo ezithathelwanayo nezitholwayo. Ikhono le-Compound lokusebenzisana nama-macromolecule ezinto eziphilayo kwenza kube ngumuntu ozongenela ukhetho ukuze kuhlolwe okunye kulezi zindawo zokwelapha.
Indlela yokwenza isenzo
Indlela yokusebenza kwe-2- (4-aminophyl) -1h-Benzimidazole-5-Amine ihlobene ngokuyinhloko nekhono layo lokuvimbela ama-enzyme athile nezindlela ezibalulekile ukuze uthole ukwanda kwamaseli nokusinda. Isibonelo, ingasebenza njenge-inhibitor yama-kinasus, ama-enzyme adlala izindima ezibalulekile ezindleleni zokusayina ezihambisana nokukhula kweseli yomdlavuza. Ngokuvimba lezi zindlela, i-APBIA ingakha amanga we-apoptosis (ukushona kwamaseli ahlelwe) kumaseli angenangqondo, ngaleyo ndlela kunciphisa ukukhula kwesimila.
Ucwaningo Nentuthuko
Ucwaningo oluqhubekayo lugxile ekuthuthukiseni izakhiwo zokhermacological of apbia. Lokhu kufaka phakathi ukuthuthukisa i-solubity yayo, ama-bioavailability kanye nokucaciswa kwama-receptors ahlosiwe. Ososayensi futhi bafunda imiphumela emibi yokuphepha kanye nemiphumela emibi, okuyizinto ezibalulekile kwinqubo yokuthuthukiswa kwezidakamizwa. Izifundo ze-preferline zibalulekile ukuthola inkomba yokwelapha ye-apbia futhi iqinisekise ukuthi ingasetshenziswa ngempumelelo esimweni somtholampilo.
Ekuphetheni
Ngamafuphi, 2- (4-Aminophyl) -1h-Benzimidazole-5-Amine (APBIA, i-CAS 76211-86-5) iyindawo ethembisayo emkhakheni wamakhemikhali wezokwelapha. Isakhiwo saso esiyingqayizivele nezinhlelo zokusebenza ezingaba khona ekwelapheni umdlavuza nezinye izifo zikwenza kube yisihloko sokucwaninga esibalulekile. Njengoba ucwaningo luqhubeka, u-Apbia angavula indlela yamasu amasha okulashwa angathinta kakhulu ukunakekelwa kweziguli. Ukuhlolwa okuqhubekayo kwezindlela zabo nemiphumela yabo kuzofaka isandla ekuqondeni okubanzi kwezicelo zokutholakala kwezidakamizwa ze-benzimidazole derivatives ekuthuthukisweni kwezidakamizwa.
Isikhathi sePosi: Nov-11-2024