I-Guanidineacetic acid (GAA),nge-Chemical Abstracts Service (CAS) inombolo ye-352-97-6, i-compound eye yatsala ingqalelo kwiinkalo ezahlukeneyo, ngakumbi i-biochemistry kunye nesondlo. Njenge-derivative ye-guanidine, i-GAA idlala indima ebalulekileyo kwi-synthesis ye-creatine, i-compound ebalulekileyo ye-metabolism yamandla kwi-muscle tissue. Ukuqonda imisebenzi kunye nokusetyenziswa kwe-guanidacetic acid kunokubonelela ngokubaluleka kwayo kwimpilo kunye nokuphucula ukusebenza.
I-biochemistry
Guanidineacetic acidyaziwa kakhulu ngomsebenzi wayo njengesandulela kwi-creatine. I-Creatine yimolekyuli ebalulekileyo enceda ukuvelisa i-adenosine triphosphate (ATP), eyona nto ithwala amandla kwiiseli. Umzimba wenza i-creatine esuka kwi-GAA kwizintso kwaye uyithuthe kwimisipha kunye nengqondo. Le nkqubo ibalulekile ekugcineni amanqanaba amandla kunye nokuxhasa umsebenzi wokuqonda ngexesha lokuzilolonga okuphezulu.
Ukuguqulwa kwe-GAA kwi-creatine kubandakanya amanyathelo amaninzi e-enzymatic, apho i-guanidinoacetate methyltransferase (GAMT) idlala indima ebalulekileyo. Le enzyme ibangela ukuhanjiswa kweqela le-methyl ukusuka kwi-S-adenosylmethionine ukuya kwi-guanidineacetic acid, yenze i-creatine. Ngoko ke, i-GAA ingaphezulu nje kwekhompawundi elula; yinxalenye ebalulekileyo yeendlela ze-metabolic ezigcina ukuveliswa kwamandla emzimbeni.
IiNzuzo zeNtshukumo kunye nokuzilolonga
Ngenxa yendima yayo kwi-creatine synthesis, i-guanidine acetic acid ithandwa ngabadlali kunye nabathandi bokuqina. Ukongezwa nge-GAA kunokuphucula ukusebenza komzimba ngokwandisa ukufumaneka kwe-creatine kwizihlunu. Oku kuphucula amandla, ukuphuma kwamandla, kunye nokunyamezela ngexesha lokuzilolonga okuphezulu. Ukongeza,I-GAAukuxhaswa kunokunceda ukunciphisa ukudinwa kunye nokubuyisela ngokukhawuleza emva kokuzivocavoca, okwenza kube yinto ekhangayo kwabo babandakanyeka kwiirejimeni zoqeqesho olungqongqo.
Uphando lubonisa ukuba ukuxhaswa kwe-GAA kunokunyusa ubunzima bemisipha kunye nokuphucula ukubunjwa komzimba. Oku kunenzuzo ngakumbi kubadlali abafuna ukuphucula ukusebenza kwabo ngelixa begcina imizimba ebhityileyo. Ukongeza, i-GAA ixhasa umsebenzi wokuqonda, obaluleke kakhulu kubadlali abafuna ukuhlala begxile kwaye bacinge ngokucacileyo ngexesha lokhuphiswano.
Izicelo ezinokubakho zonyango
Ukongeza kwiinzuzo zokuzilolonga, ukusetyenziswa okunokubakho konyango lwe-guanidine acetic acid kuyaphononongwa. Olunye uphando lucebisa ukuba i-GAA inokuba neepropathi ze-neuroprotective, iyenza ibe ngumgqatswa wophando kwizifo ze-neurodeergenerative. Ukukwazi kwe-GAA ukunyusa amanqanaba okudala kwengqondo kunokubonelela ngokhuseleko kwizifo ezifana ne-Alzheimer's kunye nesifo sika-Parkinson, apho amandla e-metabolism ahlala esengozini.
Ukongeza, indima yeI-GAAekulawuleni ukuphazamiseka kwemetabolism ethile kuye kwaphononongwa. Ikhono layo lokuchaphazela i-metabolism yamandla inokuba nefuthe kwizifo ezifana nesifo sikashukela apho ukusetyenziswa kwamandla kuphazamiseka. Ngokuphucula ukusebenza kakuhle kwemveliso yamandla, i-GAA inokunceda ukulawula ngcono amanqanaba eswekile yegazi.
Ukuququmbela
Isishwankathelo,I-guanidine acetate (GAA) yikhompawundi enemisebenzi ebalulekileyo ye-biochemical, ngokuyinhloko njengesandulela kwi-creatine. Indima yayo kwi-metabolism yamandla ibalulekile kubadlali abafuna ukuphucula ukusebenza kunye nokubuyisela. Ukongeza, uphando oluqhubekayo malunga nokubanakho konyango luqaqambisa ukuguquguquka kwe-GAA ngaphaya kwesondlo sezemidlalo. Njengoko ukuqonda kwethu le khompawundi kuqhubeka nokuguquka, i-guanidine acetic acid inokudlala indima ebaluleke kakhulu ekusebenzeni kwezemidlalo kunye nokulawula impilo.
Ixesha lokuposa: Nov-04-2024