2- (4-Aminophenyl) -1h-Bebimidaliso-5-Amine, edla ngokubhekiswa kwi-apbia, yindawo ye-APBIA, yinxalenye ye-CASS 7621-86-5. Ngenxa yepropathi yayo eyahlukileyo kunye nezicelo ezinokubakho, le postit itsalele ingqalelo kwiinkalo ezahlukeneyo, ngakumbi kumacandelo eekhemisi zamayeza kunye nophando lweziyobisi.
Isakhiwo sekhemikhali kunye neePropathi
Isakhiwo se-molecular se-apbia sisekwe kwi-Bezimidalisole, esiyi-bicyclic ye-bicyclic esenziwe ngomsesane we-bentzene ye-bentzene kunye neringi ye-Imidazole. Ubukho beqela le-4-aminophenyl luphucula ukuvela kwayo kunye nokusebenzisana neethagethi zebhayiloji. Olu lungiselelo lolwakhiwo lubalulekile kuba lunegalelo lomsebenzi webhayiloji yendawo, esenza ukuba ibe ngumdla wokuphucula iziyobisi.
Isicelo kwi-Cheminal Chemistry
Esona sixhobo siphambili se-2- (4-Aminophenyl) -1h-Bebimidaliso-5-Amine ukwindawo yokuphuhliswa kwamayeza. Abaphandi baphonononge amandla ayo njengesiyobisi esichasene nomhlaza. I-Benzimimole moid yaziwa ngamandla ayo ukuthintela ii-enzymes ezahlukeneyo kunye nee-recertors ezithatha inxaxheba kwinkqubela phambili yomhlaza. Ngokutshintsha ubume be-apbia, izazinzulu zijolise ekuphuculeni ukusebenza ngokufezekileyo kwaye ukukhetha ngokuchasene nemigca yeseli yomhlaza othile.
Ukongeza, i-apbia ifundwa ngendima yayo ekunyangeni nezinye izifo, kubandakanya nezifo ezosulelayo nezine-neurodegenege. Isakhono sokunxibelelana ne-sucromolecules senza ukuba singumgqatswa wokuphathwa gadalala kwezi ndawo zonyango.
Indlela yesenzo
Indlela yesenzo sesenzo se-2- (4-Aminophenyl) -1h-BenziImididaliso-5-Amine ngokuyintloko inxulumene nokwazi kwako ukuthintela i-enzymes kunye neendlela ezibaluleke kakhulu kwiseli kunye nokusinda. Umzekelo, inokwenza into njenge-inhibitit ye-kinases, e-enzymes edlala indima ebalulekileyo kwiindlela zokubonisa indlela ehambelana nokukhula kweseli yomhlaza. Ngokuthintela le ndlela, i-Apbia ingayifaka i-Apoptosis (ekufeni kweseli) kwiiseli ezingalunganga, ngaloo ndlela kuncitshiswa ukukhula kwamathumba.
Uphando nophuhliso
Uphando oluqhubekayo lujolise ekuqhubeni iipropathi zekhemesti ze-apbia. Oku kubandakanya ukuphuculwa kwezomelezi, kufungelelwayo kunye nokuqina kweethagethi zethagethi. Izazinzulu zifunda ukhuseleko lwequmrhu kwaye zinokubakho iziphumo ebezingalindelekanga, ezizinto eziphambili kwinkqubo yokuphucula iziyobisi. Izifundo ezikhoyo zibalulekile ukumisela isalathiso sonyango lwe-apbia kwaye siqinisekise ukuba inokusetyenziswa ngokufanelekileyo kwisimo sekliniki.
Ukuququmbela
Isishwankathelo, 2- (4-Aminophenyl) -1h-Bebimidaliso-5-Amine (Apbia, i-Apbia, i-Apbia, i-Apbia ,-5-5) yindawo ethembisa kwi-chemistry ye-chemistry. Ulwakhiwo lwayo olukhethekileyo kunye nezicelo ezinokubakho ekunyangeni umhlaza kunye nezinye izifo zenza isihloko sophando olubalulekileyo. Njengoko uphando luqhubela phambili, i-apbia inokwenza indlela yezicwangciso-qhinga zonyango ezintsha ezinokuthi zichaphazele kakhulu ukhathalelo lwezigulana. Ukuqhubeka nokuxhaphaka kwendlela yabo kwaye ngokungathandabuzekiyo kuya kuba negalelo ekuqondeni ngokubanzi malunga nokusetyenziswa kwe-Bezimidalisole ekuPhuhlisweni kweziyobisi.
IXESHA LOKUQALA: UNv-11 ukuya ku-1124