I-2-(4-Aminophenyl) -1H-benzimidazole-5-amine, edla ngokubizwa ngokuba yi-APBIA, i-compound kunye nenombolo ye-CAS 7621-86-5. Ngenxa yezakhiwo zayo ezizodwa kunye nokusetyenziswa okunokwenzeka, le khompawundi iye yatsala ingqalelo kwiinkalo ezahlukeneyo, ngakumbi kwiinkalo zekhemistri yamayeza kunye nophando lweziyobisi.
Ubume bemichiza kunye neempawu
Ulwakhiwo lwemolekyuli ye-APBIA lusekwe kwibenzimidazole, eyibhayisekile eyenziwe ngeringi yebenzene edityanisiweyo kunye neringi imidazole. Ubukho beqela le-4-aminophenyl kwandisa ukusebenza kwakhona kunye nokusebenzisana kunye neethagethi zezinto eziphilayo. Olu lungelelwaniso lolwakhiwo lubalulekile kuba lunegalelo kumsebenzi webhayoloji wekhompawundi, nto leyo eyenza ibe ngumxholo womdla kuphuhliso lwamachiza.
Isicelo kwiChemistry yezonyango
Enye yezinto eziphambili zokusetyenziswa kwe-2-(4-aminophenyl) -1H-benzimidazole-5-amine kuphuhliso lwamachiza. Abaphandi baye baphonononga amandla ayo njengechiza elichasene nomhlaza. I-benzimidazole moiety iyaziwa ngokukwazi ukuthintela ii-enzymes ezahlukeneyo kunye ne-receptors ezibandakanyekayo ekuqhubekeni komhlaza. Ngokuguqula ubume bekhemikhali be-APBIA, izazinzulu zijolise ekuphuculeni ukusebenza kwayo kunye nokukhetha ngokuchasene nemigca ethile yeeseli zomhlaza.
Ukongeza, i-APBIA ifundelwa indima yayo ekunyangeni ezinye izifo, kubandakanya izifo ezosulelayo kunye ne-neurodeergenerative. Ikhono lekhompawundi lokusebenzisana kunye ne-biological macromolecules yenza ukuba ibe ngumviwa wokuhlola ngakumbi kwezi ndawo zonyango.
Indlela yokwenza
Indlela yokusebenza ye-2-(4-aminophenyl) -1H-benzimidazole-5-amine inxulumene ngokukodwa nokukwazi kwayo ukuvimbela i-enzymes ezithile kunye neendlela ezibaluleke kakhulu kwi-cell proliferation kunye nokuphila. Ngokomzekelo, inokusebenza njenge-inhibitor ye-kinases, i-enzymes edlala indima ebalulekileyo ekuboniseni iindlela ezinxulumene nokukhula kweeseli zomhlaza. Ngokuthintela ezi ndlela, i-APBIA inokubangela i-apoptosis (ukufa kweseli ecwangcisiweyo) kwiiseli ezinobungozi, ngaloo ndlela inciphisa ukukhula kwethumba.
Uphando nophuhliso
Uphando oluqhubekayo lugxile ekuphuculeni iimpawu ze-pharmacological ze-APBIA. Oku kubandakanya ukuphucula ukunyibilika kwayo, i-bioavailability kunye nokuchaneka kwe-receptors ekujoliswe kuyo. Iingcali zenzululwazi zikwafunda ukhuseleko lwekhompawundi kunye neziphumo ebezingalindelekanga ezinokuthi zibekho, eziyimiba ephambili kwinkqubo yophuhliso lwamachiza. Izifundo zangaphambi kweklinikhi zibalulekile ukumisela isalathiso sonyango se-APBIA kwaye siqinisekise ukuba sinokusetyenziswa ngokufanelekileyo kwimeko yeklinikhi.
Ukuququmbela
Isishwankathelo, i-2- (4-aminophenyl) -1H-benzimidazole-5-amine (APBIA, i-CAS 7621-86-5) i-compound ethembisayo kwintsimi ye-chemistry yamayeza. Ubume bayo obukhethekileyo kunye nezicelo ezinokubakho ekunyangeni umhlaza kunye nezinye izifo zenza ukuba ibe sisihloko esibalulekileyo sophando. Njengoko uphando luqhubela phambili, i-APBIA inokuvula indlela yeendlela ezintsha zonyango ezinokuchaphazela kakhulu ukhathalelo lwesigulane. Uphononongo oluqhubekayo lweendlela zabo kunye neziphumo ngokungathandabuzekiyo kuya kuba negalelo ekuqondeni okubanzi kwezicelo ze-benzimidazole derivatives kuphuhliso lwamachiza.
Ixesha lokuposa: Nov-11-2024