guanidineacetic acid (GAA),le Chemical Abstracts Service (CAS) nomoro 352-97-6, ke motsoako o khahlileng tlhokomelo likarolong tse sa tšoaneng, haholo-holo biochemistry le phepo e nepahetseng. E le derivative ea guanidine, GAA e bapala karolo ea bohlokoa tlhahisong ea creatine, motsoako oa bohlokoa bakeng sa metabolism ea matla meleng ea mesifa. Ho utloisisa mesebetsi le ts'ebeliso ea guanidacetic acid e ka fana ka temohisiso ea bohlokoa ba eona ho bophelo bo botle le ho ntlafatsa ts'ebetso.
Biochemistry
Guanidineacetic acide tsebahala haholo ka ts'ebetso ea eona e le selelekela sa popo. Creatine ke molek'hule ea bohlokoa e thusang ho hlahisa adenosine triphosphate (ATP), e leng eona e tsamaisang matla liseleng. 'Mele o kopanya creatine ho tsoa ho GAA liphio ebe o e fetisetsa mesifa le boko. Ts'ebetso ena e bohlokoa bakeng sa ho boloka maemo a matla le ho ts'ehetsa ts'ebetso ea kelello nakong ea boikoetliso bo matla haholo.
Phetoho ea GAA ho creatine e kenyelletsa mehato e mengata ea enzymatic, moo guanidinoacetate methyltransferase (GAMT) e phethang karolo ea bohlokoa. Enzyme ena e hlohlelletsa phetiso ea sehlopha sa methyl ho tloha ho S-adenosylmethionine ho ea ho guanidineacetic acid, ho etsa creatine. Ka hona, GAA e feta feela motsoako o bonolo; ke karolo ea bohlokoa ea litsela tsa metabolic tse bolokang tlhahiso ea matla 'meleng.
Melemo ea Motsamao le Boikoetliso
Ka lebaka la karolo ea eona ho motsoako oa creatine, guanidine acetic acid e ratoa ke baatlelete le batho ba chesehelang boikoetliso ba 'mele. Ho tlatselletsa ka GAA ho ka ntlafatsa ts'ebetso ea 'mele ka ho eketsa ho ba teng ha creatine mesifang. Sena se ntlafatsa matla, tlhahiso ea matla, le mamello nakong ea boikoetliso bo matla haholo. Ho feta moo,GAAtlatsetso e ka thusa ho fokotsa mokhathala le ho potlakisa ho hlaphoheloa ka mor'a ho ikoetlisa, ho etsa hore e be khetho e khahlehang bakeng sa ba kenyang mekhoa e matla ea koetliso.
Lipatlisiso li bontša hore tlatsetso ea GAA e ka eketsa boima ba mesifa le ho ntlafatsa sebopeho sa 'mele. Sena se molemo haholo ho baatlelete ba batlang ho ntlafatsa ts'ebetso ea bona ha ba ntse ba boloka 'mele o otlolohileng. Ho feta moo, GAA e ts'ehetsa ts'ebetso ea kelello, e leng bohlokoa ho baatlelete ba hlokang ho lula ba tsepamisitse maikutlo le ho nahana hantle nakong ea tlholisano.
Lisebelisoa tse ka 'nang tsa E-ba Phekolo
Ntle le melemo ea eona ea boikoetliso, tšebeliso e ka bang teng ea kalafo ea guanidine acetic acid le eona e ntse e hlahlojoa. Liphuputso tse ling li fana ka maikutlo a hore GAA e kanna ea ba le thepa ea ts'ireletso ea methapo, e e etsa mokhethoa oa ho etsa lipatlisiso ka mafu a neurodegenerative. Bokhoni ba GAA ba ho eketsa maemo a boko bo ka fana ka tšireletso khahlanong le mafu a kang Alzheimer's le Parkinson's disease, moo metabolism ea matla e atisang ho senyeha.
Ho phaella moo, karolo eaGAAho laoleheng mathata a itseng a metabolism ho boetse ho ithutoa. Bokhoni ba eona ba ho susumetsa metabolism ea matla bo ka ba le litlamorao ho mafu a kang lefu la tsoekere moo tšebeliso ea matla e sitisoang. Ka ho ntlafatsa ts'ebetso ea tlhahiso ea matla, GAA e ka thusa ho laola maemo a tsoekere ea mali hamolemo.
Ha re phethela
Ka kakaretso,guanidine acetate (GAA) ke motsoako o nang le mesebetsi ea bohlokoa ea lik'hemik'hale, haholo-holo e le selelekela sa pōpo. Karolo ea eona ho metabolism ea matla e bohlokoa ho baatlelete ba batlang ho ntlafatsa ts'ebetso le ho hlaphoheloa. Ho feta moo, lipatlisiso tse tsoelang pele mabapi le bokhoni ba eona ba kalafo li totobatsa ho tenyetseha ha GAA ho feta phepo ea lipapali. Ha kutloisiso ea rona ea motsoako ona e ntse e tsoela pele ho fetoha, guanidine acetic acid e ka 'na ea e-ba le karolo ea bohlokoa ho feta ts'ebetsong ea lipapali le tsamaiso ea bophelo bo botle.
Nako ea poso: Nov-04-2024