Chii chinonzi 2- (4-aminoponyl) -1h-Benzimidazol-5-Amine inoshandiswa?

2-(4-Aminophenyl)-1H-benzimidazole-5-amine, often referred to as APBIA, is a compound with CAS number 7621-86-5. Nekuda kwezvinhu zvaro zvakasarudzika zvimiro zvemagetsi uye zvingangoita zvekushandisa, izvi zvinokonzeresa kutarisisa muminda dzakasiyana-siyana, kunyanya muminda yemishonga yemishonga yemishonga uye kutsvagisa zvinodhaka.

Makemikari chimiro uye zvivakwa

Iyo molecular chimiro cheAPBIA yakavakirwa paBenzimidazole, iyo iri bhasikoro chimiro chakaumbwa neisimusi yakasarudzika yeBenzene mhete uye chindori cheJidazole. Kuvapo kweiyo 4-Aminofenyl boka rinokwidziridza kuenderana uye kudyidzana neyebhinzi target. Uku kurongwa kwakasimba kwakakosha nekuti kunobatsira kune chiitiko chebenzi chemubatanidzwa, zvichiita kuti ive nyaya yekufarira zvinodhaka.

Chikumbiro muMushonga Chemistry

Imwe yemashandisirwo makuru e2- (4-Aminophyl) -1H-Benzimidazole-5-Amine iri mukuvandudzwa kwemishonga yemishonga. Vatsvagiri vava kuongorora zvarinogona kuita seanodhaka-cancer dhizaini. Iyo yeBenzimidazole moones inozivikanwa nekugona kwayo kuti inhibit dzakasiyana-siyana enzymes uye Receptors akabatanidzwa mujenya kufambira mberi. Nekugadziridza mamiriro eAPBIA, masayendisiti ane chinangwa chekusimudzira kugona kwake uye kusarudzika kurwisa chaiwo macancer cancer mitsara.

Uyezve, APBIA iri kudzidzwa basa rayo mukurapa zvimwe zvirwere, kusanganisira hutachiona hwehutachiona uye nehurwere hwehuswa. Iko kukwanisa kukwanisa kupindirana ne biological macromolecules kunoita kuti ive mukwikwidzi kuti uwedzere kuongorora munzvimbo idzi dzekurapa.

Michina yekuita

Mashandiro echiitiko che2- (4-Aminophenel) -1h-Benzimidazole-5-Amine inonyanya kuwirirana nekugona kwayo yekudzivirira mamwe ma enzymes uye nzira dzinotsoropodza huwandu hwesero uye kupona. Semuenzaniso, inogona kuita seishingori yekinases, enzymes inotamba mabasa akakosha mukusaina nzira dzakabatana nekenza yekukura cell. Nekuvhara nzira idzi, APBIA inogona kuunza Apeptosis (yakarongerwa rufu) mumariko ane marara, nekudaro achideredza kukura kwebundu.

Tsvagurudzo uye Kubudirira

Kuenderera mberi kwekutsvaga kunotarisisa pane inogadzirisa zvivakwa zve pharmacological yeAPBIA. Izvi zvinosanganisira kuvandudza kwayo solubility, bioavhalubility uye chokwadi kune vanoteedzera anotora. Masayendisiti ari zvakare kudzidza kuchengetedzwa kwemakwenzi uye kunogona kuitika mhedzisiro, ayo akakosha zvinhu mune zvinodhaka kukura kwezvinodhaka. Preclinical zvidzidzo zvakakosha kuti uone iyo yekurapa index yeAPBIA uye ive nechokwadi chekuti inogona kushandiswa zvinobudirira mune imwe kiriniki mamiriro.

Mumhedziso

Mukupfupikisa, 2- (4-Aminekuva 1 -1h-Benzimidazole-5-Amine (APBIA, CAP 7621-86--5) ndeyekuvimbisa komiti yemishonga yemishonga yemishonga. Yayo yakasarudzika mamiriro uye zvingangoita zvekushandisa mukurapa cancer uye zvimwe zvirwere zvinoita kuti ive yakakosha yekutsvagisa nyaya. Sezvo tsvagiridzo inofambira mberi, APBIA inogona kuve yakagadzirira nzira yerudzi rutsva urwo runogona kukanganisa zvakanyanya? Kuenderera mberi kwekuongorora kwemuchina wavo uye mhedzisiro hazvizivikanwe zvichiratidza kunzwisisika kwekunzwisisa kwekushandisa kweBenzimidazole Deventives mukusimudzira zvinodhaka.