2-(4-Aminophenyl)-1H-benzimidazole-5-amine, inowanzonzi APBIA, isanganiswa ine CAS nhamba 7621-86-5. Nekuda kweiyo yakasarudzika zvimiro uye zvingangoita mashandisiro, komisheni iyi yakwezva kutarisa munzvimbo dzakasiyana siyana, kunyanya muminda yemishonga kemikari uye kutsvaga kwezvinodhaka.
Chimiro chemakemikari uye maitiro
Iyo molecular structure yeAPBIA yakavakirwa pabenzimidazole, inova chimiro chebicyclic chinoumbwa nemhete yebenzene yakasanganiswa uye mhete imidazole. Kuvapo kweboka re4-aminophenyl kunowedzera reactivity yayo uye kushamwaridzana nezvinangwa zvehupenyu. Iyi dhizaini yekumisikidza yakakosha nekuti inobatsira kune biological chiitiko chekomboni, zvichiita kuti ive nyaya yekufarira mukuvandudza zvinodhaka.
Kushandisa muMedicinal Chemistry
Imwe yekushandiswa kukuru kwe2-(4-aminophenyl) -1H-benzimidazole-5-amine iri mukugadzirwa kwemishonga. Vatsvagiri vanga vachiongorora kugona kwayo semushonga unorwisa cancer. Iyo benzimidazole moiety inozivikanwa nekugona kwayo kuvharidzira akasiyana enzymes uye mareceptor anobatanidzwa mukufambira mberi kwegomarara. Nekugadzirisa chimiro chemakemikari eAPBIA, masayendisiti ane chinangwa chekusimudzira kushanda kwayo uye kusarudzwa kunopesana nemitsara yekenza yesero.
Pamusoro pezvo, APBIA iri kudzidzwa nezvebasa rayo mukurapa zvimwe zvirwere, kusanganisira kutapukira uye neurodegenerative zvirwere. Iko kugona kwekomboni kusangana nebiological macromolecules inoita kuti ive mumiriri wekuwedzera kuongororwa munzvimbo idzi dzekurapa.
Nzira yekuita
Iyo nzira yekuita ye2-(4-aminophenyl) -1H-benzimidazole-5-amine inonyanya kuenderana nekukwanisa kwayo kuvharidzira mamwe ma enzymes uye nzira dzinokosha pakuwedzera kwesero uye kurarama. Semuenzaniso, inogona kuita se inhibitor ye kinases, ma enzymes anotamba mabasa akakosha mukusaina nzira dzine chekuita nekenza sero kukura. Nekuvhara nzira idzi, APBIA inogona kukurudzira apoptosis (yakarongwa sero kufa) mumaseru akaipa, nekudaro ichideredza kukura kwebundu.
Tsvakurudzo uye Kubudirira
Tsvagiridzo inoenderera yakanangana nekugadzirisa iyo pharmacological zvimiro zve APBIA. Izvi zvinosanganisira kuvandudza kunyungudika kwayo, bioavailability uye chaiyo kune inotarirwa receptors. Masayendisiti ari kudzidzawo kuchengetedzwa kwekomboni uye zvinogona kuitika, zvinova zvinhu zvakakosha mukugadzirwa kwezvinodhaka. Preclinical zvidzidzo zvakakosha kuti uone therapeutic index ye APBIA uye kuve nechokwadi kuti inogona kushandiswa nemazvo munzvimbo yekiriniki.
Mukupedzisa
Muchidimbu, 2-(4-aminophenyl)-1H-benzimidazole-5-amine (APBIA, CAS 7621-86-5) inhengo inovimbisa mumunda wemakemikari emishonga. Chimiro chayo chakasiyana uye chinogona kushandiswa mukurapa cancer uye zvimwe zvirwere zvinoita kuti ive yakakosha yekutsvagisa musoro. Sezvo tsvagiridzo inofambira mberi, APBIA inogona kuvhura nzira yemaitiro matsva ekurapa anogona kukanganisa zvakanyanya kutarisirwa kwevarwere. Kuenderera mberi nekuongororwa kwemaitiro avo nemhedzisiro pasina mubvunzo zvichabatsira mukunzwisisa kwakadzama kwekushandiswa kwebenzimidazole kubva mukugadzirwa kwezvinodhaka.
Nguva yekutumira: Nov-11-2024