1. Hormone fa'atonu e fa'atalanoaina le photoperiodicity i mammals. Taofi le cerebellar nitric oxide synthetase
2. Melatonine e mafai ona faʻaaogaina i le faʻaosoina o le moe, faʻaleleia le paʻu o le circadian, antioxidant, free radical scavenger
3. Immunostimulant;Melatonin receptor ligand
4. Melatonin ei ai aafiaga lavelave i ala apoptotic, inhibiting apoptosis i sela puipuia ma neu ae faaleleia apoptotic cell oti o sela o le kanesa. Taofi le fa'atuputeleina/metastasis o sela o le kanesa o le susu e ala i le taofia o le fa'aogaina o le estrogen.