Guanidineacetic acid (GAA),ya na Ọrụ Abstracts Chemical (CAS) nọmba 352-97-6, bụ ihe dọtara mmasị na mpaghara dị iche iche, ọkachasị biochemistry na nri na-edozi ahụ. Dị ka ihe sitere na guanidine, GAA na-arụ ọrụ dị mkpa na njikọ nke creatine, ihe dị mkpa maka metabolism ike na anụ ahụ. Ịghọta ọrụ na ngwa nke guanidacetic acid nwere ike inye nghọta maka mkpa ọ dị na ahụike na imeziwanye arụmọrụ.
Biochemistry
Guanidineacetic acidA maara nke ọma maka ọrụ ya dị ka ihe mmalite nke creatine. Creatine bụ molekul dị mkpa nke na-enyere aka ịmepụta adenosine triphosphate (ATP), bụ isi ihe na-ebu ike na sel. Ahụ na-emepụta creatine sitere na GAA na akụrụ na-ebuga ya na akwara na ụbụrụ. Usoro a dị oke mkpa maka ịnọgide na-enwe ike ike na ịkwado ọrụ ọgụgụ isi n'oge mmega ahụ dị elu.
Ntughari nke GAA na creatine gụnyere ọtụtụ usoro enzymatic, nke guanidinoacetate methyltransferase (GAMT) na-arụ ọrụ dị mkpa. Enzyme a na-akwalite ịnyefe otu methyl site na S-adenosylmethionine na guanidineacetic acid, na-akpụ creatine. Ya mere, GAA abụghị naanị ihe dị mfe; ọ bụ akụkụ dị mkpa nke ụzọ metabolic na-ejigide mmepụta ume n'ime ahụ.
Uru nke ngagharị na mmega ahụ
N'ihi ọrụ ya na njikọ creatine, guanidine acetic acid na-ewu ewu na ndị na-eme egwuregwu na ndị na-anụ ọkụ n'obi. Ịgbakwunye GAA nwere ike ịkwalite arụmọrụ anụ ahụ site n'ịbawanye nnweta creatine na mọzụlụ. Nke a na-eme ka ike, mmepụta ike, na ntachi obi dịkwuo mma n'oge mgbatị ahụ dị elu. Ọzọkwa,GAAmgbakwunye nwere ike inye aka belata ike ọgwụgwụ na mgbake ngwa ngwa mgbe mgbatị ahụ gasịrị, na-eme ka ọ bụrụ nhọrọ mara mma maka ndị na-etinye aka na usoro ọzụzụ siri ike.
Nnyocha na-egosi na mgbakwunye GAA nwere ike ịbawanye ụba anụ ahụ ma melite nhazi ahụ. Nke a bara uru karịsịa maka ndị na-eme egwuregwu na-achọ imeziwanye arụmọrụ ha ka ha na-ejigide ahụ ike. Na mgbakwunye, GAA na-akwado ọrụ ọgụgụ isi, nke dị oke mkpa maka ndị na-eme egwuregwu chọrọ itinye uche na iche echiche nke ọma n'oge asọmpi.
Ngwa ọgwụgwọ enwere ike
Na mgbakwunye na uru mmega ahụ ya, a na-enyocha ngwa ọgwụgwọ guanidine acetic acid nwere ike ime. Ụfọdụ ọmụmụ na-atụ aro na GAA nwere ike ịnwe ihe ndị na-adịghị ahụkebe, na-eme ka ọ bụrụ onye nyocha maka nchọpụta n'ime ọrịa neurodegenerative. Ikike GAA na-abawanye ọkwa creatine ụbụrụ nwere ike inye nchebe pụọ na ọrịa ndị dị ka Alzheimer na ọrịa Parkinson, ebe a na-emebikarị metabolism ike.
Ọzọkwa, ọrụ nkeGAAA mụọlakwa ihe gbasara ịchịkwa ụfọdụ ọrịa metabolic. Ikike ya imetụta metabolism ike nwere ike ịmetụta ọrịa ndị dị ka ọrịa shuga ebe a na-akpaghasị ojiji ike. Site na imeziwanye nrụpụta ike ike, GAA nwere ike inye aka jikwaa ọkwa shuga dị n'ọbara nke ọma.
Na ngwụcha
Na nchịkọta,guanidine acetate (GAA) bụ ngwakọta nwere ọrụ biochemical dị mkpa, nke bụ isi dị ka ihe mmalite nke creatine. Ọrụ ya na metabolism ike bara uru nye ndị na-eme egwuregwu na-achọ imeziwanye arụmọrụ na mgbake. Na mgbakwunye, nyocha gara n'ihu n'ime ikike ọgwụgwọ ya na-egosi ịdị iche iche nke GAA karịa nri egwuregwu. Ka nghọta anyị banyere ogige a na-aga n'ihu na-etolite, guanidine acetic acid nwere ike ịrụ ọrụ dị mkpa na-arụ ọrụ egwuregwu na njikwa ahụike.
Oge nzipu: Nov-04-2024