2-(4-Aminophenyl)-1H-benzimidazole-5-amine, feem ntau hu ua APBIA, yog ib tug compound nrog CAS tus naj npawb 7621-86-5. Vim nws cov yam ntxwv tshwj xeeb thiab muaj peev xwm siv tau, qhov sib xyaw no tau nyiam nyob hauv ntau qhov chaw, tshwj xeeb tshaj yog nyob rau hauv thaj chaw tshuaj chemistry thiab kev tshawb fawb tshuaj.
Cov qauv tshuaj thiab cov khoom
Cov qauv molecular ntawm APBIA yog raws li benzimidazole, uas yog cov qauv bicyclic tsim los ntawm fused benzene nplhaib thiab lub nplhaib imidazole. Lub xub ntiag ntawm 4-aminophenyl pab pawg txhim kho nws cov reactivity thiab kev cuam tshuam nrog cov hom phiaj lom neeg. Cov txheej txheem kev teeb tsa no yog qhov tseem ceeb vim tias nws txhawb nqa kev ua haujlwm lom neeg ntawm cov khoom sib txuas, ua rau nws muaj kev txaus siab rau kev tsim tshuaj.
Daim ntawv thov hauv Medicinal Chemistry
Ib qho tseem ceeb ntawm kev siv 2-(4-aminophenyl)-1H-benzimidazole-5-amine yog nyob rau hauv kev tsim kho tshuaj. Cov kws tshawb fawb tau tshawb nrhiav nws lub peev xwm ua tshuaj tiv thaiv kab mob cancer. benzimidazole moiety paub txog nws lub peev xwm los inhibit ntau yam enzymes thiab receptors koom nrog hauv kev mob qog noj ntshav. Los ntawm kev hloov kho APBIA cov qauv tshuaj, cov kws tshawb fawb tsom los txhim kho nws cov txiaj ntsig thiab kev xaiv tiv thaiv kab mob qog noj ntshav tshwj xeeb.
Tsis tas li ntawd, APBIA tab tom kawm txog nws lub luag haujlwm hauv kev kho lwm yam kab mob, suav nrog cov kab mob sib kis thiab neurodegenerative. Qhov sib xyaw ua ke muaj peev xwm cuam tshuam nrog cov macromolecules lom neeg ua rau nws yog tus neeg sib tw rau kev tshawb nrhiav ntxiv hauv cov chaw kho mob.
Mechanism ntawm kev ua
Cov txheej txheem ntawm kev ua ntawm 2-(4-aminophenyl)-1H-benzimidazole-5-amine yog feem ntau cuam tshuam nrog nws lub peev xwm los inhibit qee cov enzymes thiab txoj hauv kev uas tseem ceeb rau kev loj hlob ntawm tes thiab kev ciaj sia. Piv txwv li, nws tuaj yeem ua tus inhibitor ntawm kinases, enzymes uas ua lub luag haujlwm tseem ceeb hauv kev qhia txoj hauv kev cuam tshuam nrog kev loj hlob ntawm cov qog nqaij hlav cancer. Los ntawm kev thaiv txoj hauv kev no, APBIA tuaj yeem ua rau apoptosis (programmed cell tuag) hauv cov hlwb malignant, yog li txo cov qog loj hlob.
Kev tshawb fawb thiab kev loj hlob
Kev tshawb fawb tsis tu ncua yog tsom rau kev ua kom zoo ntawm cov tshuaj pharmacological ntawm APBIA. Qhov no suav nrog kev txhim kho nws cov solubility, bioavailability thiab tshwj xeeb rau cov hom phiaj receptors. Cov kws tshawb fawb tseem tab tom kawm txog qhov sib xyaw ua ke ntawm kev nyab xeeb thiab muaj peev xwm tshwm sim, uas yog qhov tseem ceeb hauv txoj kev txhim kho tshuaj. Cov kev tshawb fawb ua ntej yog qhov tseem ceeb los txiav txim siab kho qhov ntsuas ntawm APBIA thiab xyuas kom meej tias nws tuaj yeem siv tau zoo hauv qhov chaw kho mob.
Hauv kev xaus
Hauv cov ntsiab lus, 2-(4-aminophenyl)-1H-benzimidazole-5-amine (APBIA, CAS 7621-86-5) yog ib qho kev cog lus cog lus nyob rau hauv cov tshuaj chemistry. Nws cov qauv tshwj xeeb thiab muaj peev xwm siv tau hauv kev kho mob qog noj ntshav thiab lwm yam kab mob ua rau nws muaj txiaj ntsig kev tshawb fawb lub ntsiab lus. Raws li kev tshawb fawb txuas ntxiv mus, APBIA tuaj yeem tsim txoj hauv kev rau cov tswv yim kho tshiab uas tuaj yeem cuam tshuam rau kev saib xyuas neeg mob. Kev tshawb nrhiav txuas ntxiv ntawm lawv cov txheej txheem thiab cov teebmeem yuav ua rau muaj kev nkag siab dav dua ntawm kev siv benzimidazole derivatives hauv kev tsim tshuaj.
Post lub sij hawm: Nov-11-2024