1. Hoʻopaʻa ʻia ka Hormone e hoʻoponopono i ka photoperiodicity i nā mammals. Kāohi i ka cerebellar nitric oxide synthetase
2. Hiki ke hoʻohana ʻia ka melatonine i ka hoʻoulu ʻana i ka hiamoe, hoʻololi i ka circadian rhythm, antioxidant, free radical scavenger.
3. Immunostimulant;Melatonin receptor ligand
4. He hopena koʻikoʻi ka Melatonin ma nā ala apoptotic, e kāohi ana i ka apoptosis i loko o nā pūnaewele immune a me nā neurons akā hoʻonui i ka make apoptotic cell o nā maʻi kanesa. Kāohi i ka proliferation/metastasis o ka umauma maʻi 'aʻai maʻi ma ke kaohi 'ana estrogen receptor hana.